UNIQUE PREBIOTIC

NOBELbad Технологии и препараты для долголетия

LONGOVITER NOBEL

A new form of the product – powder packaged in mini-sachets is added to any yogurt / sour-milk product, and also comes in the form of capsules.

Innovative products of healthy nutrition for longevity «Longoviters» are based on various therapeutic and prophylactic natural supplements to yogurt, and also contain an organic prebiotic to restore and maintain normal intestinal microflora. So, according to the latest publications (2019), the state of the microbiota directly affects the rigidity of the vessels, and therefore the lifespan and the state of the cardiovascular system. DOI: 10.1113 / JP277336

WITH KURKUMA AND PATENTED PREBIOTICS

  • Increases the level of activity of the Nrf2 gene responsible for the fight against oxidants in the cells of the heart muscle and in other muscles:
    physiology.org/doi/abs/10.1152/
  • helps immunity induce apoptosis (self-destruction) of atypical cancer cells, destroys Helicobacter pylori (the causative agent of stomach ulcers, stomach cancer, one of the main causes of colorectal cancer), and also prevents the development of Alzheimer’s disease.
    molpharm.aspetjournals.org/content/70/5/1664?fbclid = IwAR08mDjSwDOCCx5zzqhlJDUVHjl6QMf3y8TbKlxgmEtQQQU6RqFZ2yiXhKQ
  • Contributes to the growth of the average life expectancy of laboratory animals by 19% suppressing the level of inflammation associated with the aging process;
    ncbi.nlm.nih.gov/pubmed/19594223 and www.ncbi.nlm.nih.gov/pubmed/17569207
  • Geroprotector – warning Alzheimer’s disease;
    https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(18)30178-0
  • As a proteasome inhibitor improves pancreatic beta cell function and insulin sensitivity in diabetic mice:
    nature.com/articles/nutd201613?fbclid=IwAR2fF7AANi6cFPv2Wr696txeo93Y1K5ssxHOz0wRFcA-epusWSYbtJ2VB1E
  • Inflammation inhibitor – and inflammation is one of the main components of the aging process;
    https://www.ncbi.nlm.nih.gov/pubmed/18841446?fbclid=IwAR2ECmcSdw4SCxqQXEYwMPvbVx2cUXDDWPqIcxGRGjbioxgApZB6qPd1-TI
    onlinelibrary.wiley.com/doi/full/10.1111/joim.12823
  • In combination with other components has a synergistic positive effect in prostate cancer:
    https://www.nature.com/articles/s41698-017-0024-z?fbclid=IwAR0srCstf45VF6QA9jsqmvfH18xpzNZpTApPdm_tntTH7_8lLUGcOAevf2k
  • Reduces insulin resistance:
    http://www.jarcp.com/3974-decreasing-levels-of-sporacetigenium-correlate-with-improved-diabetic-parameters-in-healthy-adults-consuming-msprebiotic-digestion-resistant-starch.html

C PHYSICAL TRAIN AND SPECIAL PREBIOTIC

Fisetin, which is a component of many fruits and vegetables (strawberries, apples, persimmon, onions), as well as other polyphenols (for example, resveratrol), modulates the activity of sirtuin Sirt1 [1], the activation of which prolongs life [2] not only simple organisms (yeast, worms, fruit flies), but also to mice [3], increases the level of glutathione [4], can be used to treat age-related neurodegenerative diseases [5, 6, 7] and the effects of an ischemic attack [8, 9]. In addition, it improves memory [10–12] in healthy animals and reduces methylglyoxal-dependent protein glycation [13]. Acceptance of fizetin in the late period of life increases the lifespan of wild mice.

  • [1]. Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells., https://www.ncbi.nlm.nih.gov/pubmed/26499075
  • [2]. Caloric restriction, SIRT1 and longevity., Https://www.ncbi.nlm.nih.gov/pubmed/19713122
  • [3]. Homeobox 1 in the DMH and LH., Https://www.ncbi.nlm.nih.gov/pubmed/24011076
  • [4]. Modification of multiple pathways is involved in the maintenance of neuronal function during aging by fisetin., Https://www.ncbi.nlm.nih.gov/pubmed/19756810
  • [5]. Fisetin Reduction Aging for Amplification and Amplification SAMP8 Mouse., Https://www.ncbi.nlm.nih.gov/pubmed/28575152
  • [6]. Ameliorative Effect of Fisetin on Cisplatin-Induced in Rats via Modulation of NF-κB Activation and Antioxidant Defense., Https://www.ncbi.nlm.nih.gov/pubmed/25184746
  • [7]. Neuroprotective Effects of Fisetin in Alzheimer’s and Parkinson’s Diseases: From Chemistry to Medicine., Https://www.ncbi.nlm.nih.gov/pubmed/26845554
  • [8]. Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation., Https://www.ncbi.nlm.nih.gov/pubmed/15312169
  • [9]. The Flavonoid Fisetin Attenuates Postischemic Immune Cell
  • Infiltration, Activation and Infarct Size after Transient Cerebral Middle Artery Occlusion in Mice., Https://www.ncbi.nlm.nih.gov/pubmed/22234339
  • [10]. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory., Https://www.ncbi.nlm.nih.gov/pubmed/17050681
  • [11]. Plant-Derived Flavanol (-) Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice., Https://www.ncbi.nlm.nih.gov/pubmed/17537957
  • [12]. It is a flavonoids with neuroprotective and anti- active flavonoids