REDUCING THE RISK OF ONCOLOGICAL DISEASES IN HIGHER AGE

NOBELbad Технологии и препараты для долголетия

With age, the risk of cancer increases exponentially. The drug NOBELbad reduces this risk due to the action of its constituent components.

LIKOPIN (contained in white grapefruit)

It has pronounced antioxidant properties. Lycopene reduces the risk of prostate cancer and metastasis. It has a positive effect on lung cancer.

RADIO PROTECTIVE MEANS Showing radioprotective properties on healthy tissue, it makes sense to use lycopene during radiation therapy courses.

Oxidative stress-mediated DNA damage is associated with cancer. Significantly reduces the degree of mutation arising from cell division, reducing lipid peroxidation, enhancing the activity of glutathione-dependent enzymes in gastric cancer.

Lycopene has an antiproliferative effect on gastric cancer cells by inhibiting the activation of signal-regulated kinase, causing cell cycle arrest.

Lycopene activates apoptosis (self-destruction) in gastric cancer cells by lowering Bcl-2, increasing Bax levels, caspases 3 and 8.

The p53 tumor suppressor (suppressor) is an anti-cancer gene. Lycopene can protect against the development of gastric cancer by correcting the imbalance of p53-dependent apoptosis and cell proliferation.

Lycopene prevents Helicobacter pylori, one of the causes of gastrointestinal cancer, induced increase in the production of reactive oxygen species and changes in the cell cycle in the epithelial cells of the stomach.

In addition, lycopene prevents the cleavage of PARP-1 (poly (ADP-ribose) – polymerase) enzyme, which restores DNA damage.

A meta-analysis conducted in China confirms the inverse relationship between tomato consumption and the risk of stomach cancer. The risk of stomach cancer has been significantly reduced in people consuming more lycopene. High serum lycopene was associated with a low risk of gastric cancer.

Studies show that eating enough tomatoes or tomato-based products, even for a short period of time, reduces the risk of breast cancer in postmenopausal women.

www.ncbi.nlm.nih.gov/pmc/articles/PMC2615641/
www.ncbi.nlm.nih.gov/pubmed/26287411
www.ncbi.nlm.nih.gov/pmc/articles/PMC3415693
www.ncbi.nlm.nih.gov/pmc/articles/PMC4492364
www.ncbi.nlm.nih.gov/pubmed/18223356
www.ncbi.nlm.nih.gov/pubmed/25526570
www.ncbi.nlm.nih.gov/pmc/articles/PMC3757421/
www.ncbi.nlm.nih.gov/pmc/articles/PMC3068500/
academic.oup.com/…/article…/doi/10.1210/jc.2013-3222

SPERMIDIN (contained in grapefruit)

Eating spermidine with food is associated with a decrease in overall mortality and mortality from tumor diseases in humans.
www.ncbi.nlm.nih.gov/pubmed/29955838/.

Interferes with the development of liver fibrosis and malignant hepatoma, one of the most common forms of liver cancer through the induction of MAP1S-mediated autophagy.
www.ncbi.nlm.nih.gov/pmc/articles/PMC5489339/.

Spermidine postpones the development of tumors in a model of induced lung cancer in mice.
www.ncbi.nlm.nih.gov/pubmed/27411589/.

Stimulates anti-tumor immunological surveillance. In human epidemiological studies, food intake of polyamines correlates with a decrease in cancer-related mortality. Spermidine retains mitochondrial function, has anti-inflammatory properties and prevents aging of stem cells.
www.ncbi.nlm.nih.gov/pubmed/29371440

Taking spermidine can prolong the lifespan of model organisms, including yeast, nematode, flies, and mice. Recent epidemiological evidence suggests that increased food intake of spermidine also reduces total cardiovascular and cancer-related mortality in humans.
www.ncbi.nlm.nih.gov/pmc/articles/PMC6128428/

Spermidine reduces cancer mortality in humans.
www.ncbi.nlm.nih.gov/pubmed/30354939

Polyamine spermidine in PTEN-PI3K-mTOR 1 anti-cancer strategy (mTORC1), WNT and RAS signaling, offers potential combination therapies that will have significant clinical perspectives.
www.nature.com/articles/s41568-018-0050-3

FUKOKSANTIN (contained in algae extract)

Fucoxanthin causes apoptosis and enhances the antiproliferative effect of gamma-ligand PPAR troglitazone in colon cancer cells.
www.sciencedirect.com/science/article/pii/S0304416504002223?via%3Dihub

Fucoxanthin induces apoptosis in human HL-60 leukemia cells through the Bcl-xL ROS-mediated pathway.
www.sciencedirect.com/science/article/pii/S0887233310001414?via%3Dihub

Adult T-cell leukemia (ATL) is a fatal malignant neoplasm of T-lymphocytes caused by infection of the human T-cell leukosis virus type 1 (HTLV-1), and remains incurable. Among carotenoids, fucoxanthin has antitumor activity by inhibiting the viability of T-cell line cells infected with HTLV-1 and ATL cells with fucoxanthin. In contrast, other carotenoids, β-carotene and astaxanthin, had a moderate inhibitory effect on the T-cell line infected with HTLV-1. It is important that uninfected cell lines and normal peripheral blood mononuclear cells were resistant to fucoxanthin. Fucoxanthin induces cell cycle arrest during the G1 phase, reducing the expression of cyclin D1, cyclin D2, CDK4, and CDK6, and inducing GADD45α expression, and causing apoptosis by reducing the expression of Bcl-2, XIAP, cIAP2, and survivin. Induced apoptosis was associated with the activation of caspase-3, -8 and -9. Fucoxanthin inhibits IκBα phosphorylation and JunD expression, which leads to inactivation of the nuclear factor-κB and activator-1 protein. Mice with severe combined immunodeficiency causing tumors caused by inoculation of HTLV-1 infected T cells responded to treatment https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.23860

Anticarcinogenic effect of fucoxanthin, extracted from brown macroalgae and diatoms, is the strongest among carotenoids.
repository.marine-research.org/bitstream/299011/5066/1/80-83.pdf

Fucoxanthin has a strong antioxidant properties in anoxic conditions, and most tissues under physiological conditions have a low oxygen content. In addition, typical antioxidants are usually proton donors (ascorbic acid, α-tocopherol, glutathione), and fucoxanthin is an electron donor for antiradical activity. The combination of these distinctive properties is rarely found among natural food ingredients (Riccioni et al., 2011). Free radicals and oxidative stress involved in the pathogenesis of cancer. In this way, carotenoids, due to their antioxidant properties, are effective anticancer molecules (Peng et al., 2011; D’Orazio el al., 2012).
file: ///Users/apple/Downloads/algol_2014_24_1_4.pdf

NR-NAD + (nicotinamide riboside)

The increase in life expectancy in recent decades has been accompanied by an increase in the incidence of aging, including cancer. Disease and cancer are integral parts of the aging process, and aging can be considered a disease of aging. NAD + levels decrease with aging, due to changes in metabolic reactions leading to the synthesis of NAD +. Models for age-related diseases and cancer show abbreviations of NAD + pools. Increasing NAD + with precursors such as NAM, NMN or NR can increase life expectancy and prevent age-related diseases and cancer in animal models.
www.cell.com/trends/cancer/fulltext/S2405-8033(17)30105-X

The oxidized form of cellular nicotinamide adenine dinucleotide (NAD +) is currently being intensively studied in the science of longevity. NAD + is shown as an important factor associated with the formation and prevention of cancer. Depletion of NAD + with age can play a major role in the formation of cancer, limiting energy production, DNA repair, genomic stability, and signaling. Disruption of any of these processes may increase the risk of developing cancer due to a violation of the stability of the genome. NAD + content is a critical protective factor in early carcinogenesis. Namely, the recovery of NAD + can prevent or reverse the phenotype of malignant cells in the early stages by inducing cell repair and a stress-adaptive response, as well as regulating cell cycle arrest and apoptotic removal of damaged cells.
www.scitechnol.com/peer-review/nad-in-cancer-prevention-and-treatment-pros-and-cons-zR4d.php?article_id=5285

Suppresses inflammation in the liver, reducing IL 6. TNF, NLRP3
www.ncbi.nlm.nih.gov/pubmed/25974041

Naringin / Naringenin

Shows versatile anti-cancer properties. Read more: http://young-life.ru/science/naringin/